MicroRNAs in the Neural Retina
Joint Authors
Cooper, Nigel G. F.
Andreeva, Kalina
Source
International Journal of Genomics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The health and function of the visual system rely on a collaborative interaction between diverse classes of molecular regulators.
One of these classes consists of transcription factors, which are known to bind to DNA and control the transcription activities of their target genes.
For a long time, it was thought that the transcription factors were the only regulators of gene expression.
More recently, however, a novel class of regulators emerged.
This class consists of a large number of small noncoding endogenous RNAs, namely, miRNAs.
The miRNAs compose an essential component of posttranscriptional gene regulation, since they ultimately control the fate of gene transcripts.
The retina, as a part of the central nervous system, is a well-established model for unraveling the molecular mechanisms underlying neuronal and glial functions.
Numerous recent efforts have been made towards identification of miRNAs and their inferred roles in the visual pathway.
In this review, we summarize the current state of our knowledge regarding the expression and function of miRNA in the neural retina and we discuss their potential uses as biomarkers for some retinal disorders.
American Psychological Association (APA)
Andreeva, Kalina& Cooper, Nigel G. F.. 2014. MicroRNAs in the Neural Retina. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-451160
Modern Language Association (MLA)
Andreeva, Kalina& Cooper, Nigel G. F.. MicroRNAs in the Neural Retina. International Journal of Genomics No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-451160
American Medical Association (AMA)
Andreeva, Kalina& Cooper, Nigel G. F.. MicroRNAs in the Neural Retina. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-451160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451160