The Effect of Platelet-Rich Plasma on Pain, Function, and Quality of Life of Patients with Knee Osteoarthritis
Joint Authors
Rayegani, Seyed Mansoor
Babaee, Marzieh
Raeissadat, Seyed Ahmad
Ghorbani, Elham
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
New studies in the management of knee osteoarthritis have focused on modern therapeutic methods stimulating cartilage healing process.
In the present study, we evaluated the effects of 2 courses of leucocyte-rich PRP (LR-PRP) injections on patients’ QOL and functions and also the relationship between the PRP concentration and mentioned variables.
Material and Methods.
Sixty-five patients were evaluated.
For each participant, WOMAC and the native (Farsi) edition of the SF-36 questionnaire were filled.
Two courses of LR-PRP injections with 4-week interval were used.
After 6 months, SF-36 and WOMAC questionnaires were filled again for each patient.
Results.
60 patients were included in the final analysis.
The mean platelet concentrations and white blood cell in PRP was 5-fold increase and 220 per microliter, respectively.
The mean total WOMAC revealed significant change (P=0.001).
In SF-36, the mean changes of 2 major physical and mental domains were meaningful (P=0.001).
Discussion.
In our study, 2 injections of PRP, with 4-week interval, improved the pain, stiffness, and functional capacity.
Improvements in QOL (both PCS and MCS) were meaningful after injections.
These changes were more significant in physical domains.
PRP injection may be an alternative therapy in selective patients resistant to current nonsurgical treatments of knee osteoarthritis.
American Psychological Association (APA)
Raeissadat, Seyed Ahmad& Rayegani, Seyed Mansoor& Babaee, Marzieh& Ghorbani, Elham. 2013. The Effect of Platelet-Rich Plasma on Pain, Function, and Quality of Life of Patients with Knee Osteoarthritis. Pain Research and Treatment،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-451169
Modern Language Association (MLA)
Raeissadat, Seyed Ahmad…[et al.]. The Effect of Platelet-Rich Plasma on Pain, Function, and Quality of Life of Patients with Knee Osteoarthritis. Pain Research and Treatment No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-451169
American Medical Association (AMA)
Raeissadat, Seyed Ahmad& Rayegani, Seyed Mansoor& Babaee, Marzieh& Ghorbani, Elham. The Effect of Platelet-Rich Plasma on Pain, Function, and Quality of Life of Patients with Knee Osteoarthritis. Pain Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-451169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451169