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Royal Jelly Facilitates Restoration of the Cognitive Ability in Trimethyltin-Intoxicated Mice
Joint Authors
Hattori, Noriko
Ohta, Shozo
Sakamoto, Takashi
Furukawa, Shoei
Mishima, Satoshi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Trimethyltin (TMT) is a toxic organotin compound that induces acute neuronal death selectively in the hippocampal dentate gyrus (DG) followed by cognition impairment; however the TMT-injured hippocampal DG itself is reported to regenerate the neuronal cell layer through rapid enhancement of neurogenesis.
Neural stem/progenitor cells (NS/NPCs) are present in the adult hippocampal DG, and generate neurons that can function for the cognition ability.
Therefore, we investigated whether royal jelly (RJ) stimulates the regenerating processes of the TMT-injured hippocampal DG, and found that orally administered RJ significantly increased the number of DG granule cells and simultaneously improved the cognitive impairment.
Furthermore, we have already shown that RJ facilitates neurogenesis of cultured NS/NPCs.
These present results, taken together with previous observations, suggest that the orally administered RJ may be a promising avenue for ameliorating neuronal function by regenerating hippocampal granule cells that function in the cognition process.
American Psychological Association (APA)
Hattori, Noriko& Ohta, Shozo& Sakamoto, Takashi& Mishima, Satoshi& Furukawa, Shoei. 2010. Royal Jelly Facilitates Restoration of the Cognitive Ability in Trimethyltin-Intoxicated Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-451170
Modern Language Association (MLA)
Hattori, Noriko…[et al.]. Royal Jelly Facilitates Restoration of the Cognitive Ability in Trimethyltin-Intoxicated Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-451170
American Medical Association (AMA)
Hattori, Noriko& Ohta, Shozo& Sakamoto, Takashi& Mishima, Satoshi& Furukawa, Shoei. Royal Jelly Facilitates Restoration of the Cognitive Ability in Trimethyltin-Intoxicated Mice. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-451170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451170