Prostate Cancer and Bone : The Elective Affinities
Joint Authors
Angelucci, Adriano
Rucci, Nadia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The onset of metastases dramatically changes the prognosis of prostate cancer patients, determining increased morbidity and a drastic fall in survival expectancy.
Bone is a common site of metastases in few types of cancer, and it represents the most frequent metastatic site in prostate cancer.
Of note, the prevalence of tumor relapse to the bone appears to be increasing over the years, likely due to a longer overall survival of prostate cancer patients.
Bone tropism represents an intriguing challenge for researchers also because the preference of prostate cancer cells for the bone is the result of a sequential series of targetable molecular events.
Many factors have been associated with the peculiar ability of prostate cancer cells to migrate in bone marrow and to determine mixed osteoblastic/osteolytic lesions.
As anticipated by the success of current targeted therapy aimed to block bone resorption, a better understanding of molecular affinity between prostate cancer and bone microenvironment will permit us to cure bone metastasis and to improve prognosis of prostate cancer patients.
American Psychological Association (APA)
Rucci, Nadia& Angelucci, Adriano. 2014. Prostate Cancer and Bone : The Elective Affinities. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-451176
Modern Language Association (MLA)
Rucci, Nadia& Angelucci, Adriano. Prostate Cancer and Bone : The Elective Affinities. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-451176
American Medical Association (AMA)
Rucci, Nadia& Angelucci, Adriano. Prostate Cancer and Bone : The Elective Affinities. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-451176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451176