Fc-Gamma Receptor 3B Copy Number Variation Is Not a Risk Factor for Behçet’s Disease
Joint Authors
Rischmueller, Maureen
Lester, Susan E.
Saeedfar, Kayvan
Ziaei, Naghmeh
Dunstan, Emma
Bayat, Noushin
Black, Rachel
Hill, Catherine L.
Shahram, Farhad
Nadji, Abdolhadi
Davatchi, Fereydoun
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Behçet’s disease (BD) is an immune-mediated systemic vasculitis associated with HLAB51.
Other gene associations are likely and may provide further insight into the pathogenesis of this disease.
Fc-gamma receptors play an important role in regulating immune function.
Copy number variation (CNV) of the Fc-gamma receptor 3B (FCGR3B) gene is associated with other inflammatory conditions and may also play a role in BD.
The aim of this study was to determine whether CNV of the FCGR3B gene is associated with BD or its clinical features.
FCGR3B copy number was determined for 187 Iranian patients and 178 ethnicity-matched controls using quantitative real-time PCR.
The genotype frequencies were comparable in both BD patients and controls.
The odds ratio for low copy number (<2CN) was 0.6 (P=0.16) and the odds ratio for high copy number (>2CN) was 0.75 (P=0.50).
There was no association found between high or low CN of the FCGR3B gene and BD or its clinical features in this Iranian population.
We are the first to report this finding which, when looked at in the context of other genetic studies, gives us further insight into the complex pathogenesis of BD.
American Psychological Association (APA)
Black, Rachel& Lester, Susan E.& Dunstan, Emma& Shahram, Farhad& Nadji, Abdolhadi& Bayat, Noushin…[et al.]. 2012. Fc-Gamma Receptor 3B Copy Number Variation Is Not a Risk Factor for Behçet’s Disease. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-451186
Modern Language Association (MLA)
Black, Rachel…[et al.]. Fc-Gamma Receptor 3B Copy Number Variation Is Not a Risk Factor for Behçet’s Disease. International Journal of Rheumatology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-451186
American Medical Association (AMA)
Black, Rachel& Lester, Susan E.& Dunstan, Emma& Shahram, Farhad& Nadji, Abdolhadi& Bayat, Noushin…[et al.]. Fc-Gamma Receptor 3B Copy Number Variation Is Not a Risk Factor for Behçet’s Disease. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-451186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451186