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Pathogenesis of Renal Failure in Multiple Myeloma : Any Role of Contrast Media?
Joint Authors
Mussap, Michele
Merlini, Giampaolo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The spectrum of kidney disease-associated monoclonal immunoglobulin and plasma cell malignancies is remarkably broad and encompasses nearly all nephropathologic entities.
Multiple myeloma with kidney impairment at presentation is a medical emergency since the recovery of kidney function is associated with survival benefits.
In most cases, kidney impairment may be the first clinical manifestation of malignant plasma cell dyscrasias like multiple myeloma and light chain amyloidosis.
Multiple myeloma per se cannot be considered a main risk factor for developing acute kidney injury following intravascular administration of iodinated contrast media.
The risk is increased by comorbidities such as chronic kidney disease, diabetes, hypercalcemia, dehydration, and use of nephrotoxic drugs.
Before the administration of contrast media, the current recommended laboratory tests for assessing kidney function are serum creatinine measurement and the estimation of glomerular filtration rate by using the CKD-EPI equation.
The assessment of Bence Jones proteinuria is unnecessary for evaluating the risk of kidney failure in patients with multiple myeloma, since this test cannot be considered a surrogate biomarker of kidney function.
American Psychological Association (APA)
Mussap, Michele& Merlini, Giampaolo. 2014. Pathogenesis of Renal Failure in Multiple Myeloma : Any Role of Contrast Media?. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-451191
Modern Language Association (MLA)
Mussap, Michele& Merlini, Giampaolo. Pathogenesis of Renal Failure in Multiple Myeloma : Any Role of Contrast Media?. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-451191
American Medical Association (AMA)
Mussap, Michele& Merlini, Giampaolo. Pathogenesis of Renal Failure in Multiple Myeloma : Any Role of Contrast Media?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-451191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451191