Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group
Joint Authors
Behzadi, Parisa
Amini, Massoud
Torabi, Firouzeh
Aminorroaya, Ashraf
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Oxidized low density lipoprotein (ox-LDL) is a product of oxidative stress.
In this cross-sectional study, we compared the ox-LDL concentrations in diabetic patients with normoalbuminuria (n=28), microalbuminuria (n=28), and macroalbuminuria (n=28) with their first degree relatives (n=28) and healthy control people (n=31).
They were selected by consecutive patient selection method.
The ox-LDL level was assayed using ELISA.
We measured blood pressure, lipid profile, fasting plasma glucose (FPG), and HbA1c in all groups.
There was no significant difference in ox-LDL concentrations among normoalbuminuric, microalbuminuric, and macroalbuminuric diabetic groups.
In diabetic patients with micro- and macroalbuminuria, ox-LDL concentration was higher than their first degree relatives (P=0.04 and P=0.03) and control group (P=0.001 and P=0.03, resp.).
In normoalbuminuric diabetic persons, ox-LDL concentration was just higher than that of healthy people (P=0.02).
There was no statistically significant difference in ox-LDL levels between normoalbuminuric diabetic patients and their first degree relatives.
In conclusion, the presence and progression of albuminuria in diabetic patients are not related to ox-LDL concentration and genetic predisposition influences the plasma OX-LDL level.
Larger sample size is needed to confirm this conclusion in future studies.
American Psychological Association (APA)
Behzadi, Parisa& Torabi, Firouzeh& Amini, Massoud& Aminorroaya, Ashraf. 2012. Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-451197
Modern Language Association (MLA)
Behzadi, Parisa…[et al.]. Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group. International Journal of Endocrinology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-451197
American Medical Association (AMA)
Behzadi, Parisa& Torabi, Firouzeh& Amini, Massoud& Aminorroaya, Ashraf. Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-451197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451197