Serum Metabolic Profile in Multiple Sclerosis Patients
Joint Authors
Gullotta, Stefano
Nociti, Viviana
Amorini, Angela Maria
Longo, Salvatore
D'Urso, Serafina
Picardi, Marika
Tavazzi, Barbara
Lazzarino, Giuseppe
Batocchi, Anna Paola
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Multiple sclerosis (MS) is a progressive demyelinating process considered as an autoimmune disease, although the causes of this pathology have not been yet fully established.
Similarly to other neurodegenerations, MS is characterized by a series of biochemical changes affecting to different extent neuronal functions; great attention has been given to oxidative/nitrosative stress and to alterations in mitochondrial functions.
According to previous data, MS patients show significant changes in the circulating concentrations of different metabolites, although it is still unclear whether uric acid undergoes to decrease, increase, or no change under this pathological condition.
In this study, we report the serum metabolic profile in terms of purines, pyrimidines, creatinine, malondialdehyde, ascorbic acid, nitrite, and nitrate in a group of 170 MS patients.
The results show increase in circulating uric acid and other oxypurines (hypoxanthine and xanthine), as well as in uridine and β-pseudouridine.
The concomitant increase in circulating creatinine, malondialdehyde, nitrite, and nitrate, and decrease in ascorbic acid, demonstrates that MS induces alteration in energy metabolism and in oxidants/antioxidants balance that can be monitored in serum of MS patients.
American Psychological Association (APA)
Tavazzi, Barbara& Batocchi, Anna Paola& Amorini, Angela Maria& Nociti, Viviana& D'Urso, Serafina& Longo, Salvatore…[et al.]. 2011. Serum Metabolic Profile in Multiple Sclerosis Patients. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-451198
Modern Language Association (MLA)
Tavazzi, Barbara…[et al.]. Serum Metabolic Profile in Multiple Sclerosis Patients. Multiple Sclerosis International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-451198
American Medical Association (AMA)
Tavazzi, Barbara& Batocchi, Anna Paola& Amorini, Angela Maria& Nociti, Viviana& D'Urso, Serafina& Longo, Salvatore…[et al.]. Serum Metabolic Profile in Multiple Sclerosis Patients. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-451198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451198