Ibuprofen Can Induce Syndrome of Inappropriate Diuresis in Healthy Young Patients
Joint Authors
Moalic, Jean-Luc
Simon, Fabrice
Roche, Céline
Ragot, Céline
Oliver, Manuela
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 30-year-old caucasian woman, without past medical history or known drug use, was admitted to the emergency department for persistent fever and arthralgias.
The laboratory analysis showed moderate hypoosmolar hyponatremia (Na: 132 mmol/L, osmolality: 239 mOsm/L), normal sodium excretion (<20 mmol/L), and a high urinary osmolality (415 mOsm/L).
Later, she deteriorated with seizures and deeper hyponatremia (Na: 113 mmol/L) and so was moved to the critical care unit.
At first, no obvious aetiology was found, the patient was euvolemic, as she was well hydrated and lacked concerning findings of heart failure, renal disease, or liver cirrhosis.
A syndrome of inappropriate diuresis (SIAD) was proposed, and corrective measures were started immediately to reduce her hyponatremia, including restriction of fluid intake.
The administration of intravenous hypertonic saline solution permitted normal neurological status to be restored and corrected the sodium concentration but induced reversible acute renal failure.
Further investigation revealed that the patient had ingested 8 g ibuprofen two days before admission.
After other aetiologies were ruled out, drug-induced SIAD due to ibuprofen was the most likely diagnosis for this patient.
SIAD-associated hyponatremia and acute renal failure are rare side effects of nonsteroidal anti-inflammatory drugs, particularly in young people.
Therefore, this case may represent a unique case of NSAID-induced SIAD and highlight the need to obtain thorough medication histories and exclude all other potential causes in hyponatremic patients.
American Psychological Association (APA)
Roche, Céline& Ragot, Céline& Moalic, Jean-Luc& Simon, Fabrice& Oliver, Manuela. 2013. Ibuprofen Can Induce Syndrome of Inappropriate Diuresis in Healthy Young Patients. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-451209
Modern Language Association (MLA)
Roche, Céline…[et al.]. Ibuprofen Can Induce Syndrome of Inappropriate Diuresis in Healthy Young Patients. Case Reports in Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-451209
American Medical Association (AMA)
Roche, Céline& Ragot, Céline& Moalic, Jean-Luc& Simon, Fabrice& Oliver, Manuela. Ibuprofen Can Induce Syndrome of Inappropriate Diuresis in Healthy Young Patients. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-451209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451209