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Mix and Inject : Reaction Initiation by Diffusion for Time-Resolved Macromolecular Crystallography
Author
Source
Advances in Condensed Matter Physics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Time-resolved macromolecular crystallography unifies structure determination with chemical kinetics, since the structures of transient states and chemical and kinetic mechanisms can be determined simultaneously from the same data.
To start a reaction in an enzyme, typically, an initially inactive substrate present in the crystal is activated.
This has particular disadvantages that are circumvented when active substrate is directly provided by diffusion.
However, then it is prohibitive to use macroscopic crystals because diffusion times become too long.
With small micro- and nanocrystals diffusion times are adequately short for most enzymes and the reaction can be swiftly initiated.
We demonstrate here that a time-resolved crystallographic experiment becomes feasible by mixing substrate with enzyme nanocrystals which are subsequently injected into the X-ray beam of a pulsed X-ray source.
American Psychological Association (APA)
Schmidt, Marius. 2013. Mix and Inject : Reaction Initiation by Diffusion for Time-Resolved Macromolecular Crystallography. Advances in Condensed Matter Physics،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-451210
Modern Language Association (MLA)
Schmidt, Marius. Mix and Inject : Reaction Initiation by Diffusion for Time-Resolved Macromolecular Crystallography. Advances in Condensed Matter Physics No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-451210
American Medical Association (AMA)
Schmidt, Marius. Mix and Inject : Reaction Initiation by Diffusion for Time-Resolved Macromolecular Crystallography. Advances in Condensed Matter Physics. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-451210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451210