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Low-Dose UVA Radiation-Induced Adaptive Response in Cultured Human Dermal Fibroblasts
Joint Authors
Liang, Jie
Chen, Hulin
Yang, Huilan
Liu, Zhongrong
Li, Xuemei
Source
International Journal of Photoenergy
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To investigate the mechanism of the adaptive response induced by low-dose ultraviolet A (UVA) radiation.
Methods.
Cultured dermal fibroblasts were irradiated by a lethal dose of UVA (86.4 J/cm2) with preirradiation of single or repetitive low dose of UVA (7.2 J/cm2).
Alterations of cellular morphology were observed by light microscope and electron microscope.
Cell cycle and cellular apoptosis were assayed by flow cytometer.
The extent of DNA damage was determined by single-cell gel electrophoresis (SCGE).
Results.
The cultured dermal fibroblasts, with pretreatment of single or repetitive irradiation of 7.2 J/cm2 UVA relieved toxic reaction of cellular morphology and arrest of cell cycle, decreased apoptosis ratio, reduced DNA chain breakage, and accelerated DNA repair caused by subsequent 86.4 J/cm2 UVA irradiation.
Compared with nonpretreatment groups, all those differences were significant (P<0.01 or P<0.05).
Conclusions.
The adaptation reaction might depend on the accumulated dose of low-dose UVA irradiation.
Low-dose UVA radiation might induce adaptive response that may protect cultured dermal fibroblasts from the subsequent challenged dose of UVA damage.
The duration and protective capability of the adaptive reaction might be related to the accumulated dose of low-dose UVA Irradiation.
American Psychological Association (APA)
Liu, Zhongrong& Chen, Hulin& Yang, Huilan& Liang, Jie& Li, Xuemei. 2012. Low-Dose UVA Radiation-Induced Adaptive Response in Cultured Human Dermal Fibroblasts. International Journal of Photoenergy،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-451223
Modern Language Association (MLA)
Liu, Zhongrong…[et al.]. Low-Dose UVA Radiation-Induced Adaptive Response in Cultured Human Dermal Fibroblasts. International Journal of Photoenergy No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-451223
American Medical Association (AMA)
Liu, Zhongrong& Chen, Hulin& Yang, Huilan& Liang, Jie& Li, Xuemei. Low-Dose UVA Radiation-Induced Adaptive Response in Cultured Human Dermal Fibroblasts. International Journal of Photoenergy. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-451223
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451223