Antidiabetic Activities of Abutilon indicum (L.) Sweet Are Mediated by Enhancement of Adipocyte Differentiation and Activation of the GLUT1 Promoter
Joint Authors
Baek, Seung Joon
Temsiririrkkul, Rungravi
Lee, Seong-Ho
Krisanapun, Chutwadee
Peungvicha, Penchom
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Abutilon indicum (L.) Sweet is an Asian phytomedicine traditionally used to treat several disorders, including diabetes mellitus.
However, molecular mechanisms supporting the antidiabetic effect of A.
indicum L.
remain unknown.
The aim of this study was to evaluate whether extract of A.
indicum L.
improves insulin sensitivity.
First, we observed the antidiabetic activity of aqueous extract of the entire plant (leaves, twigs and roots) of A.
indicum L.
on postprandial plasma glucose in diabetic rats.
The subsequent experiments revealed that butanol fractions of the extract bind to PPARγ and activate 3T3-L1 differentiation.
To measure glucose uptake enhanced by insulin-like activity, we used rat diaphragm incubated with various concentrations of the crude extract and found that the extract enhances glucose consumption in the incubated solution.
Our data also indicate that the crude extract and the fractions (water and butanol) did not affect the activity of kinases involved in Akt and GSK-3β pathways; however, the reporter assay showed that the crude extract could activate glucose transporter 1 (GLUT1) promoter activity.
These results suggest that the extract from A.
indicum L.
may be beneficial for reducing insulin resistance through its potency in regulating adipocyte differentiation through PPARγ agonist activity, and increasing glucose utilization via GLUT1.
American Psychological Association (APA)
Krisanapun, Chutwadee& Lee, Seong-Ho& Peungvicha, Penchom& Temsiririrkkul, Rungravi& Baek, Seung Joon. 2011. Antidiabetic Activities of Abutilon indicum (L.) Sweet Are Mediated by Enhancement of Adipocyte Differentiation and Activation of the GLUT1 Promoter. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-451250
Modern Language Association (MLA)
Krisanapun, Chutwadee…[et al.]. Antidiabetic Activities of Abutilon indicum (L.) Sweet Are Mediated by Enhancement of Adipocyte Differentiation and Activation of the GLUT1 Promoter. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-451250
American Medical Association (AMA)
Krisanapun, Chutwadee& Lee, Seong-Ho& Peungvicha, Penchom& Temsiririrkkul, Rungravi& Baek, Seung Joon. Antidiabetic Activities of Abutilon indicum (L.) Sweet Are Mediated by Enhancement of Adipocyte Differentiation and Activation of the GLUT1 Promoter. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-451250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451250