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Diabetic Neuropathy and Oxidative Stress : Therapeutic Perspectives
Joint Authors
Abdollahi, Mohammad
Hosseini, Asieh
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Diabetic neuropathy (DN) is a widespread disabling disorder comprising peripheral nerves' damage.
DN develops on a background of hyperglycemia and an entangled metabolic imbalance, mainly oxidative stress.
The majority of related pathways like polyol, advanced glycation end products, poly-ADP-ribose polymerase, hexosamine, and protein kinase c all originated from initial oxidative stress.
To date, no absolute cure for DN has been defined; although some drugs are conventionally used, much more can be found if all pathophysiological links with oxidative stress would be taken into account.
In this paper, although current therapies for DN have been reviewed, we have mainly focused on the links between DN and oxidative stress and therapies on the horizon, such as inhibitors of protein kinase C, aldose reductase, and advanced glycation.
With reference to oxidative stress and the related pathways, the following new drugs are under study such as taurine, acetyl-L-carnitine, alpha lipoic acid, protein kinase C inhibitor (ruboxistaurin), aldose reductase inhibitors (fidarestat, epalrestat, ranirestat), advanced glycation end product inhibitors (benfotiamine, aspirin, aminoguanidine), the hexosamine pathway inhibitor (benfotiamine), inhibitor of poly ADP-ribose polymerase (nicotinamide), and angiotensin-converting enzyme inhibitor (trandolapril).
The development of modern drugs to treat DN is a real challenge and needs intensive long-term comparative trials.
American Psychological Association (APA)
Hosseini, Asieh& Abdollahi, Mohammad. 2013. Diabetic Neuropathy and Oxidative Stress : Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-451276
Modern Language Association (MLA)
Hosseini, Asieh& Abdollahi, Mohammad. Diabetic Neuropathy and Oxidative Stress : Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-451276
American Medical Association (AMA)
Hosseini, Asieh& Abdollahi, Mohammad. Diabetic Neuropathy and Oxidative Stress : Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-451276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451276