Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration
Joint Authors
Camara-Lemarroy, Carlos Rodrigo
Fernandez-Garza, Nancy Esthela
González-Moreno, Emmanuel Irineo
Guzman-de la Garza, Francisco Javier
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
After peripheral nerve injury, a process of axonal degradation, debris clearance, and subsequent regeneration is initiated by complex local signaling, called Wallerian degeneration (WD).
This process is in part mediated by neuroglia as well as infiltrating inflammatory cells and regulated by inflammatory mediators such as cytokines, chemokines, and the activation of transcription factors also related to the inflammatory response.
Part of this neuroimmune signaling is mediated by the innate immune system, including arachidonic acid (AA) derivatives such as prostaglandins and leukotrienes.
The enzymes responsible for their production, cyclooxygenases and lipooxygenases, also participate in nerve degeneration and regeneration.
The interactions between signals for nerve regeneration and neuroinflammation go all the way down to the molecular level.
In this paper, we discuss the role that AA derivatives might play during WD and nerve regeneration, and the therapeutic possibilities that arise.
American Psychological Association (APA)
Camara-Lemarroy, Carlos Rodrigo& González-Moreno, Emmanuel Irineo& Guzman-de la Garza, Francisco Javier& Fernandez-Garza, Nancy Esthela. 2012. Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-451367
Modern Language Association (MLA)
Camara-Lemarroy, Carlos Rodrigo…[et al.]. Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-451367
American Medical Association (AMA)
Camara-Lemarroy, Carlos Rodrigo& González-Moreno, Emmanuel Irineo& Guzman-de la Garza, Francisco Javier& Fernandez-Garza, Nancy Esthela. Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-451367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451367