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MAP Kinases and Prostate Cancer
Joint Authors
Fraile, Benito
Paniagua, Ricardo
Martínez-Onsurbe, Pilar
Olmedilla, Gabriel
Royuela, Mar
Rodríguez-Berriguete, Gonzalo
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The three major mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK are signal transducers involved in a broad range of cell functions including survival, apoptosis, and cell differentiation.
Whereas JNK and p38 have been generally linked to cell death and tumor suppression, ERK plays a prominent role in cell survival and tumor promotion, in response to a broad range of stimuli such as cytokines, growth factors, ultraviolet radiation, hypoxia, or pharmacological compounds.
However, there is a growing body of evidence supporting that JNK and p38 also contribute to the development of a number of malignances.
In this paper we focus on the involvement of the MAPK pathways in prostate cancer, including the less-known ERK5 pathway, as pro- or antitumor mediators, through their effects on apoptosis, survival, metastatic potential, and androgen-independent growth.
American Psychological Association (APA)
Rodríguez-Berriguete, Gonzalo& Fraile, Benito& Martínez-Onsurbe, Pilar& Olmedilla, Gabriel& Paniagua, Ricardo& Royuela, Mar. 2011. MAP Kinases and Prostate Cancer. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-451387
Modern Language Association (MLA)
Rodríguez-Berriguete, Gonzalo…[et al.]. MAP Kinases and Prostate Cancer. Journal of Signal Transduction No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-451387
American Medical Association (AMA)
Rodríguez-Berriguete, Gonzalo& Fraile, Benito& Martínez-Onsurbe, Pilar& Olmedilla, Gabriel& Paniagua, Ricardo& Royuela, Mar. MAP Kinases and Prostate Cancer. Journal of Signal Transduction. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-451387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451387