The Cold Contact Method as a Simple Drug Interaction Detection System
Joint Authors
Asyarie, Sukmadjaja
Soewandhi, Sundani Nurono
Nugrahani, Ilma
Ibrahim, Slamet
Source
Research Letters in Physical Chemistry
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The physical interaction between 2 substances frequently occurs along the mixing and manufacturing of solid drug dosage forms.
The physical interaction is generally based on coarrangement of crystal lattice of drug combination.
The cold contact method has been developed as a simple technique to detect physical interaction between 2 drugs.
This method is performed by observing new habits of cocrystal that appear on contact area of crystallization by polarization microscope and characterize this cocrystal behavior by melting point determination.
Has been evaluated by DSC, this method is proved suitable to identify eutecticum interaction of pseudoephedrine HCl-acetaminophen, peritecticum interaction of methampyrone-phenylbutazon, and solid solution interaction of amoxicillin-clavulanate, respectively.
American Psychological Association (APA)
Nugrahani, Ilma& Asyarie, Sukmadjaja& Soewandhi, Sundani Nurono& Ibrahim, Slamet. 2008. The Cold Contact Method as a Simple Drug Interaction Detection System. Research Letters in Physical Chemistry،Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-451393
Modern Language Association (MLA)
Nugrahani, Ilma…[et al.]. The Cold Contact Method as a Simple Drug Interaction Detection System. Research Letters in Physical Chemistry No. 2008 (2008), pp.1-4.
https://search.emarefa.net/detail/BIM-451393
American Medical Association (AMA)
Nugrahani, Ilma& Asyarie, Sukmadjaja& Soewandhi, Sundani Nurono& Ibrahim, Slamet. The Cold Contact Method as a Simple Drug Interaction Detection System. Research Letters in Physical Chemistry. 2008. Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-451393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451393