Antitumor Activity of Leaves from Hyptis mutabilis (A. Rich.) Briq. (Lamiaceae) in Mice Bearing Tumor
Joint Authors
Melo, Antônio Mario
Magalhães, Lucimeri Paulino Machado
de Albuquerque, Julianna Ferreira Cavalcanti
de Souza, Ivone Antonia
Ximenes, Rafael Matos
Source
Dataset Papers in Pharmacology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-02
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
The Hyptis genus has more than 400 species, many of them being used in folk medicine to treat several conditions.
Some anticancer compounds have been isolated from plants of this genus, and for that reason we decided to investigate the potential in vivo antitumor activity of extracts of leaves of Hyptis mutabilis with different polarities (hexane, methanol, water, and hot water) against two mice tumors: sarcoma 180 and Ehrlich solid tumor.
Phytochemical analysis revealed strong presence of steroids, saponins, flavonoids (mainly dihydroflavanols), and catechins.
Acute toxicity was perfomed according to the up-and-down method showing LD50 values ranging from 100 up to 2500 mg/kg.
Antitumor activity was investigated using 10% of the LD50 for each extract.
Methotrexate was used as positive control.
Both aqueous extracts showed strong inhibition of tumor growth with values up to 70% of inhibition growth for sarcoma 180.
Ehrlich solid tumor was only slight inhibited by hexane extract (38.6%).
In conclusion, the aqueous extracts of H.
mutabilis showed promising results against sarcoma 180 mice tumor.
American Psychological Association (APA)
Ximenes, Rafael Matos& Melo, Antônio Mario& Magalhães, Lucimeri Paulino Machado& de Souza, Ivone Antonia& de Albuquerque, Julianna Ferreira Cavalcanti. 2012. Antitumor Activity of Leaves from Hyptis mutabilis (A. Rich.) Briq. (Lamiaceae) in Mice Bearing Tumor. Dataset Papers in Pharmacology،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-451402
Modern Language Association (MLA)
Ximenes, Rafael Matos…[et al.]. Antitumor Activity of Leaves from Hyptis mutabilis (A. Rich.) Briq. (Lamiaceae) in Mice Bearing Tumor. Dataset Papers in Pharmacology No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-451402
American Medical Association (AMA)
Ximenes, Rafael Matos& Melo, Antônio Mario& Magalhães, Lucimeri Paulino Machado& de Souza, Ivone Antonia& de Albuquerque, Julianna Ferreira Cavalcanti. Antitumor Activity of Leaves from Hyptis mutabilis (A. Rich.) Briq. (Lamiaceae) in Mice Bearing Tumor. Dataset Papers in Pharmacology. 2012. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-451402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451402