Macrophages, PPARs, and Cancer
Joint Authors
De Baetselier, Patrick
Van den Bossche, Jan
Van Ginderachter, Jo A.
Movahedi, Kiavash
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Mononuclear phagocytes often function as control switches of the immune system, securing the balance between pro- and anti-inflammatory reactions.
For this purpose and depending on the activating stimuli, these cells can develop into different subsets: proinflammatory classically activated (M1) or anti-inflammatory alternatively activated (M2) macrophages.
The expression of the nuclear peroxisome proliferator-activated receptors (PPARs) is regulated by M1- or M2-inducing stimuli, and these receptors are generally considered to counteract inflammatory M1 macrophages, while actively promoting M2 activation.
This is of importance in a tumor context, where M1 are important initiators of inflammation-driven cancers.
As a consequence, PPAR agonists are potentially usefull for inhibiting the early phases of tumorigenesis through their antagonistic effect on M1.
In more established tumors, the macrophage phenotype is more diverse, making it more difficult to predict the outcome of PPAR agonism.
Overall, in our view current knowledge provides a sound basis for the clinical evaluation of PPAR ligands as chemopreventive agents in chronic inflammation-associated cancer development, while cautioning against the unthoughtful application of these agents as cancer therapeutics.
American Psychological Association (APA)
Van Ginderachter, Jo A.& Movahedi, Kiavash& Van den Bossche, Jan& De Baetselier, Patrick. 2008. Macrophages, PPARs, and Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-451406
Modern Language Association (MLA)
Van Ginderachter, Jo A.…[et al.]. Macrophages, PPARs, and Cancer. PPAR Research No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-451406
American Medical Association (AMA)
Van Ginderachter, Jo A.& Movahedi, Kiavash& Van den Bossche, Jan& De Baetselier, Patrick. Macrophages, PPARs, and Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-451406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451406