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Control of Transcriptional Elongation by RNA Polymerase II : A Retrospective
Joint Authors
Brannan, Kris
Bentley, David L.
Source
Genetics Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The origins of our current understanding of control of transcription elongation lie in pioneering experiments that mapped RNA polymerase II on viral and cellular genes.
These studies first uncovered the surprising excess of polymerase molecules that we now know to be situated at the at the 5′ ends of most genes in multicellular organisms.
The pileup of pol II near transcription start sites reflects a ubiquitous bottle-neck that limits elongation right at the start of the transcription elongation.
Subsequent seminal work identified conserved protein factors that positively and negatively control the flux of polymerase through this bottle-neck, and make a major contribution to control of gene expression.
American Psychological Association (APA)
Brannan, Kris& Bentley, David L.. 2012. Control of Transcriptional Elongation by RNA Polymerase II : A Retrospective. Genetics Research International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-451458
Modern Language Association (MLA)
Brannan, Kris& Bentley, David L.. Control of Transcriptional Elongation by RNA Polymerase II : A Retrospective. Genetics Research International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-451458
American Medical Association (AMA)
Brannan, Kris& Bentley, David L.. Control of Transcriptional Elongation by RNA Polymerase II : A Retrospective. Genetics Research International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-451458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451458