Neuroinflammation in the Aging Down Syndrome Brain; Lessons from Alzheimer's Disease
Author
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Down syndrome (DS) is the most genetic cause of mental retardation and is caused by the triplication of chromosome 21.
In addition to the disabilities caused early in life, DS is also noted as causing Alzheimer's-disease-like pathological changes in the brain, leading to 50–70% of DS patients showing dementia by 60–70 years of age.
Inflammation is a complex process that has a key role to play in the pathogenesis of Alzheimer's disease.
There is relatively little understood about inflammation in the DS brain and how the genetics of DS may alter this inflammatory response and change the course of disease in the DS brain.
The goal of this review is to highlight our current understanding of inflammation in Alzheimer's disease and predict how inflammation may affect the pathology of the DS brain based on this information and the known genetic changes that occur due to triplication of chromosome 21.
American Psychological Association (APA)
Wilcock, Donna M.. 2012. Neuroinflammation in the Aging Down Syndrome Brain; Lessons from Alzheimer's Disease. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-451470
Modern Language Association (MLA)
Wilcock, Donna M.. Neuroinflammation in the Aging Down Syndrome Brain; Lessons from Alzheimer's Disease. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-451470
American Medical Association (AMA)
Wilcock, Donna M.. Neuroinflammation in the Aging Down Syndrome Brain; Lessons from Alzheimer's Disease. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-451470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451470