Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy
Joint Authors
Takino, Jun-ichi
Takeuchi, Masayoshi
Yamagishi, Sho-ichi
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic complications are a leading cause of acquired blindness, end-stage renal failure, and accelerated atherosclerosis, which are associated with the disabilities and high mortality rates seen in diabetic patients.
Continuous hyperglycemia is involved in the pathogenesis of diabetic micro- and macrovascular complications via various metabolic pathways, and numerous hyperglycemia-induced metabolic and hemodynamic conditions exist, including increased generation of various types of advanced glycation end-products (AGEs).
Recently, we demonstrated that glyceraldehyde-derived AGEs, the predominant structure of toxic AGEs (TAGE), play an important role in the pathogenesis of angiopathy in diabetic patients.
Moreover, recent evidence suggests that the interaction of TAGE with the receptor for AGEs (RAGE) elicits oxidative stress generation in numerous types of cells, all of which may contribute to the pathological changes observed in diabetic complications.
In this paper, we discuss the pathophysiological role of the TAGE-RAGE system in the development and progression of diabetic retinopathy.
American Psychological Association (APA)
Takeuchi, Masayoshi& Takino, Jun-ichi& Yamagishi, Sho-ichi. 2010. Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy. Journal of Ophthalmology،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-451481
Modern Language Association (MLA)
Takeuchi, Masayoshi…[et al.]. Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy. Journal of Ophthalmology No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-451481
American Medical Association (AMA)
Takeuchi, Masayoshi& Takino, Jun-ichi& Yamagishi, Sho-ichi. Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy. Journal of Ophthalmology. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-451481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451481