Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients
Joint Authors
Lynch, Henry T.
Drescher, Kristen M.
Sharma, Poonam
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
High levels of microsatellite instability (MSI-high) are a cardinal feature of colorectal tumors from patients with Lynch Syndrome.
Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival when compared to patients diagnosed with microsatellite stable (MSS) colorectal cancer.
Many of the characteristics associated with Lynch Syndrome including enhanced survival are also observed in patients with sporadic MSI-high colorectal cancer.
In this review we will present the current state of knowledge regarding the mechanisms that are utilized by the host to control colorectal cancer in Lynch Syndrome and why these same mechanisms fail in MSS colorectal cancers.
American Psychological Association (APA)
Drescher, Kristen M.& Sharma, Poonam& Lynch, Henry T.. 2010. Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-451487
Modern Language Association (MLA)
Drescher, Kristen M.…[et al.]. Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients. Clinical and Developmental Immunology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-451487
American Medical Association (AMA)
Drescher, Kristen M.& Sharma, Poonam& Lynch, Henry T.. Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-451487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451487