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Serum p53 Antibody Is Not Associated with p53 Immunoreactivity in Patients with Pancreatobiliary Cancers
Joint Authors
Tanaka, Reina
Moriyasu, Fuminori
Mukai, Shuntaro
Ikeuchi, Nobuhito
Tsuchiya, Takayoshi
Tonozuka, Ryosuke
Oshiro, Hisashi
Kurihara, Toshio
Umeda, Junko
Itoi, Takao
Sofuni, Atsushi
Tsuji, Shujiro
Honjo, Mitsuyoshi
Ishii, Kentaro
Nagao, Toshitaka
Itokawa, Fumihide
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Recent diagnostic imaging tests contribute to improving the diagnosis of pancreatobiliary cancers.
However, it is not practical to perform these tests for all patients as screening.
Thus, less-invasive and simple screening tests are still required.
A method to detect the IgG antibody induced in serum against the p53 protein accumulating due to p53 gene mutation, as a biomarker, was developed around 1990.
Method.
35 patients with pancreatic cancer, 12 patients with biliary tract cancer, and 31 patients with benign pancreatobiliary diseases were entered into this study.
Measurement of serum anti-p53 antibody was conducted in all patients.
In addition, the rate of p53 protein overexpression was examined in those cases that could be examined pathologically.
Result.
Among all patients in the pancreatic cancer and biliary tract cancer groups, there was no patient with serum anti-p53 antibody positive value that exceeded the standard value.
The rate of p53 protein overexpression was 48.0% in the patients with pancreatobiliary cancers and 0% in the benign pancreatobiliary diseases group.
Conclusion.
Serum anti-p53 antibody measurement does not contribute to the diagnosis of pancreatobiliary cancers.
Instead, traditional p53 immunostaining still appears to be valuable in combination with standard procedures.
American Psychological Association (APA)
Umeda, Junko& Itoi, Takao& Sofuni, Atsushi& Itokawa, Fumihide& Kurihara, Toshio& Tsuchiya, Takayoshi…[et al.]. 2013. Serum p53 Antibody Is Not Associated with p53 Immunoreactivity in Patients with Pancreatobiliary Cancers. Journal of Oncology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-451504
Modern Language Association (MLA)
Umeda, Junko…[et al.]. Serum p53 Antibody Is Not Associated with p53 Immunoreactivity in Patients with Pancreatobiliary Cancers. Journal of Oncology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-451504
American Medical Association (AMA)
Umeda, Junko& Itoi, Takao& Sofuni, Atsushi& Itokawa, Fumihide& Kurihara, Toshio& Tsuchiya, Takayoshi…[et al.]. Serum p53 Antibody Is Not Associated with p53 Immunoreactivity in Patients with Pancreatobiliary Cancers. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-451504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451504