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The Prevalence of Occult Celiac Disease among Patients with Functional Dyspepsia : A Study from the Western Region of Iran
Joint Authors
Bazargan-Hejazi, Shahrzad
Keshavarz, Ali Asghar
Bashiri, Homayoon
Ahmadi, Alireza
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
The prevalence of Celiac Disease (CD) is high in Iran, and evaluation of CD is not part of the routine screening procedure for dyspeptic patients; therefore, cases of occult CD may be missed.
This study aimed to investigate the prevalence of occult CD among dyspeptic patients who presented at a gastroenterology clinic in the Western region of Iran.
Methods.
In this descriptive, cross-sectional prospective study, patients who had a history of at least 12 weeks of upper abdominal discomfort were eligible to participate in the study during a 14-month recruitment period.
Patients with a clinical or paraclinical data in favor of organic causes were excluded from the study.
Enrolled patients were screened for IgA antiendomysium antibody (EMA) and IgA antitissue transglutaminase antibody (tTG).
Those who screened positive for EMA/tTG received a confirmatory diagnostic biopsy for Marsh classification of CD.
Results.
From 225 potential participants with dyspepsia, 55 patients were excluded due to having explainable organic causes.
The study sample included 170 patients with “functional dyspepsia.” Mean age of participants was 31 years and 55.8% were female.
Twelve patients (7%) had positive tests (EMA/tTG), of which 10 were female (83.4%).
According to Rome II criteria, all twelve patients with positive tests had “dysmotility type dyspepsia.” Based on Marsh classification, six patients were consistent with “Marsh I,” four with “Marsh II,” and two with the “Marsh III” classification.
Conclusions.
In this study, the prevalence of CD in dyspeptic patients was high.
As a result, this study suggests that screening by serology tests (EMA/tTG) is justifiable for the detection of CD among functional dyspeptic patients in the tertiary centers in our country.
American Psychological Association (APA)
Keshavarz, Ali Asghar& Bashiri, Homayoon& Ahmadi, Alireza& Bazargan-Hejazi, Shahrzad. 2010. The Prevalence of Occult Celiac Disease among Patients with Functional Dyspepsia : A Study from the Western Region of Iran. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-451511
Modern Language Association (MLA)
Keshavarz, Ali Asghar…[et al.]. The Prevalence of Occult Celiac Disease among Patients with Functional Dyspepsia : A Study from the Western Region of Iran. Gastroenterology Research and Practice No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-451511
American Medical Association (AMA)
Keshavarz, Ali Asghar& Bashiri, Homayoon& Ahmadi, Alireza& Bazargan-Hejazi, Shahrzad. The Prevalence of Occult Celiac Disease among Patients with Functional Dyspepsia : A Study from the Western Region of Iran. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-451511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451511