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The Effect of Different Photoperiods in Circadian Rhythms of Per3 Knockout Mice
Joint Authors
Archer, S. N.
van der Veen, D. R.
Pedrazzoli, M.
Tufik, Sergio
von Schantz, M.
Pereira, D. S.
Gonçalves, B. S. B.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to analyse the circadian behavioural responses of mice carrying a functional knockout of the Per3 gene (Per3−/−) to different light : dark (L : D) cycles.
Male adult wild-type (WT) and Per3−/− mice were kept under 12-hour light : 12-hour dark conditions (12L : 12D) and then transferred to either a short or long photoperiod and subsequently released into total darkness.
All mice were exposed to both conditions, and behavioural activity data were acquired through running wheel activity and analysed for circadian characteristics during these conditions.
We observed that, during the transition from 12L : 12D to 16L : 8D, Per3−/− mice take approximately one additional day to synchronise to the new L : D cycle compared to WT mice.
Under these long photoperiod conditions, Per3−/− mice were more active in the light phase.
Our results suggest that Per3−/− mice are less sensitive to light.
The data presented here provides further evidence that Per3 is involved in the suppression of behavioural activity in direct response to light.
American Psychological Association (APA)
Pereira, D. S.& van der Veen, D. R.& Gonçalves, B. S. B.& Tufik, Sergio& von Schantz, M.& Archer, S. N.…[et al.]. 2014. The Effect of Different Photoperiods in Circadian Rhythms of Per3 Knockout Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-451525
Modern Language Association (MLA)
Pereira, D. S.…[et al.]. The Effect of Different Photoperiods in Circadian Rhythms of Per3 Knockout Mice. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-451525
American Medical Association (AMA)
Pereira, D. S.& van der Veen, D. R.& Gonçalves, B. S. B.& Tufik, Sergio& von Schantz, M.& Archer, S. N.…[et al.]. The Effect of Different Photoperiods in Circadian Rhythms of Per3 Knockout Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-451525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451525