How to Predict the Impact of Methylphenidate on Cardiovascular Risk in Children with Attention Deficit Disorder : Methylphenidate Improves Autonomic Dysfunction in Children with ADHD
Joint Authors
Buchhorn, Reiner
Müller, Christian
Willaschek, Christian
Norozi, Kambiz
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Background.
Although stimulants have long been touted as treatments for attention deficit disorder with or without hyperactivity (ADHD), in recent years, increasing concerns have been raised about the cardiovascular safety of these medications.
We aimed to prove if measurements of autonomic function with time domain analysis of heart rate variability (HRV) in 24-hour Holter ECG are useful to predict the risk of sudden cardiac death in ADHD children and adolescents.
Methods.
We analysed HRV obtained from children with the diagnosis of ADHD prior to (N=12) or during medical therapy (N=19) with methylphenidate (MPH), aged 10.8±2.0 years (mean ± SD), who were referred to our outpatient Paediatric Cardiology Clinic to rule out heart defect.
As a control group, we compared the HRV data of 19 age-matched healthy children without heart defect.
Results.
Average HRV parameters from 24-hour ECG in the ADHD children prior to MPH showed significant lower values compared to healthy children with respect to rMSSD (26±4 ms versus 44±10 ms, P≤0.0001) and pNN50 (6.5±2.7% versus 21.5±9.0%, P≤0.0001).
These values improved in MPH-treated children with ADHD (RMSSD: 36±8 ms; pNN50: 14.2±6.9%).
Conclusion.
Children who suffer from ADHD show significant changes in HRV that predominantly reflects diminished vagal tone, a well-known risk factor of sudden cardiac death in adults.
In our pilot study, MPH treatment improved HRV.
American Psychological Association (APA)
Buchhorn, Reiner& Müller, Christian& Willaschek, Christian& Norozi, Kambiz. 2012. How to Predict the Impact of Methylphenidate on Cardiovascular Risk in Children with Attention Deficit Disorder : Methylphenidate Improves Autonomic Dysfunction in Children with ADHD. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-451537
Modern Language Association (MLA)
Buchhorn, Reiner…[et al.]. How to Predict the Impact of Methylphenidate on Cardiovascular Risk in Children with Attention Deficit Disorder : Methylphenidate Improves Autonomic Dysfunction in Children with ADHD. ISRN Pharmacology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-451537
American Medical Association (AMA)
Buchhorn, Reiner& Müller, Christian& Willaschek, Christian& Norozi, Kambiz. How to Predict the Impact of Methylphenidate on Cardiovascular Risk in Children with Attention Deficit Disorder : Methylphenidate Improves Autonomic Dysfunction in Children with ADHD. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-451537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451537