Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The present study examined the effect of nicotine, alone and in combination with various drugs that act on the CNS, on ambulatory activity, a behavioral index for locomotion, in ICR (CD-1) strain mice.
Nicotine at 0.25–2 mg/kg acutely reduced ambulatory activity of ICR mice.
The effect of nicotine was similar to that of haloperidol and fluphenazine but distinct from that of bupropion and methylphenidate.
ICR mice developed tolerance against the inhibitory effect of nicotine on ambulatory activity when nicotine was repeatedly administered.
This effect was also distinct from bupropion and methylphenidate as they produced augmentation of their ambulation-stimulating effects in ICR mice.
Nicotine reduced the ambulation-stimulating effects of bupropion and methylphenidate as well as haloperidol and fluphenazine.
Taken together, nicotine exhibited unusual effects as a psychostimulant on ambulatory activity in ICR mice.
American Psychological Association (APA)
Umezu, Toyoshi. 2012. Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-451545
Modern Language Association (MLA)
Umezu, Toyoshi. Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice. ISRN Pharmacology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-451545
American Medical Association (AMA)
Umezu, Toyoshi. Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-451545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451545