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Principal Components Analysis of Atopy-Related Traits in a Random Sample of Children
Joint Authors
Backer, Vibeke
Thomsen, Simon Francis
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Aim.
To study the relationship between atopy-related traits in a random sample of children.
Methods.
A total of 1007 randomly selected children, 7–17 years of age, from Copenhagen, Denmark were studied.
The children were interviewed about symptoms of atopic diseases, and skin test reactivity, serum total IgE, lung function, and airway responsiveness were measured.
Principal components analysis was performed in order to examine the relationship between the different traits.
Results.
Most of the studied traits were significantly correlated.
A three-component solution explained about 55% of the variation in the observed traits.
The first component loaded most strongly on hay fever, serum total IgE, skin test reactivity and sensitisation to grass, cat and house dust mite allergen; the second factor was most associated with asthma, airway obstruction, and airway hyperresponsiveness, whereas the third factor corresponded most strongly to atopic dermatitis.
There was some indication of cross-relations between the three components with respect to serum total IgE.
Conclusion.
Asthma, hay fever, and atopic dermatitis are characterised by different sets of biomarkers suggestive of a high degree of heterogeneity within the atopic syndrome.
American Psychological Association (APA)
Thomsen, Simon Francis& Backer, Vibeke. 2011. Principal Components Analysis of Atopy-Related Traits in a Random Sample of Children. ISRN Allergy،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-451546
Modern Language Association (MLA)
Thomsen, Simon Francis& Backer, Vibeke. Principal Components Analysis of Atopy-Related Traits in a Random Sample of Children. ISRN Allergy No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-451546
American Medical Association (AMA)
Thomsen, Simon Francis& Backer, Vibeke. Principal Components Analysis of Atopy-Related Traits in a Random Sample of Children. ISRN Allergy. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-451546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451546