A Comparative Study of Five Mouse Models of Alzheimer's Disease : Cell Cycle Events Reveal New Insights into Neurons at Risk for Death
Joint Authors
Cheung, Timmy
Herrup, Karl
Chen, Jianmin
Li, Luming
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ectopic cell cycle events (CCEs) in postmitotic neurons link the neurodegenerative process in human Alzheimer's disease (AD) with the brain phenotype of transgenic mouse models with known familial AD genes.
Most reports on the mouse models use the appearance of brain amyloid pathology as a key outcome measure.
In the current paper, we focus on the induction of neurodegeneration using CCEs as markers for impending neuronal loss.
We compare 5 mouse models of familial AD for the appearance of CCEs in subcortical regions—deep cerebellar nuclei, amygdala, locus coeruleus, hippocampus, and dorsal raphe.
We find that the models differ in their CCE involvement as well as in the appearance of phosphorylated tau and amyloid deposition, suggesting that each model represents a different disease phenotype.
Comparison with the pattern of neuron death in human AD suggests that each may represent a distinctly different disease model when used in preclinical trials.
American Psychological Association (APA)
Li, Luming& Cheung, Timmy& Chen, Jianmin& Herrup, Karl. 2011. A Comparative Study of Five Mouse Models of Alzheimer's Disease : Cell Cycle Events Reveal New Insights into Neurons at Risk for Death. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-451574
Modern Language Association (MLA)
Li, Luming…[et al.]. A Comparative Study of Five Mouse Models of Alzheimer's Disease : Cell Cycle Events Reveal New Insights into Neurons at Risk for Death. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-451574
American Medical Association (AMA)
Li, Luming& Cheung, Timmy& Chen, Jianmin& Herrup, Karl. A Comparative Study of Five Mouse Models of Alzheimer's Disease : Cell Cycle Events Reveal New Insights into Neurons at Risk for Death. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-451574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451574