Populus balsamifera Extract and Its Active Component Salicortin Reduce Obesity and Attenuate Insulin Resistance in a Diet-Induced Obese Mouse Model
Joint Authors
Harbilas, Despina
Musallam, Lina
Arnason, John T.
Haddad, Pierre S.
Saleem, Ammar
Brault, Antoine
Vallerand, Diane
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Populus balsamifera L.
(BP) is a medicinal plant stemming from the traditional pharmacopoeia of the Cree of Eeyou Istchee (CEI—Northern Quebec).
In vitro screening studies revealed that it strongly inhibited adipogenesis in 3T3-L1 adipocytes, suggesting potential antiobesity activity.
Salicortin was identified, through bioassay-guided fractionation, as the active component responsible for BP’s activity.
The present study aimed to assess the potential of BP and salicortin at reducing obesity and features of the metabolic syndrome, in diet-induced obese C57Bl/6 mice.
Mice were subjected to high fat diet (HFD) for sixteen weeks, with BP (125 or 250 mg/kg) or salicortin (12.5 mg/kg) introduced in the HFD for the last eight of the sixteen weeks.
BP and salicortin effectively reduced whole body and retroperitoneal fat pad weights, as well as hepatic triglyceride accumulation.
Glycemia, insulinemia, leptin, and adiponectin levels were also improved.
This was accompanied by a small yet significant reduction in food intake in animals treated with BP.
BP and salicortin (slightly) also modulated key components in signaling pathways involved with glucose regulation and lipid oxidation in the liver, muscle, and adipose tissue.
These results confirm the validity of the CEI pharmacopoeia as alternative and complementary antiobesity and antidiabetic therapies.
American Psychological Association (APA)
Harbilas, Despina& Vallerand, Diane& Brault, Antoine& Saleem, Ammar& Arnason, John T.& Musallam, Lina…[et al.]. 2013. Populus balsamifera Extract and Its Active Component Salicortin Reduce Obesity and Attenuate Insulin Resistance in a Diet-Induced Obese Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-451661
Modern Language Association (MLA)
Harbilas, Despina…[et al.]. Populus balsamifera Extract and Its Active Component Salicortin Reduce Obesity and Attenuate Insulin Resistance in a Diet-Induced Obese Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-451661
American Medical Association (AMA)
Harbilas, Despina& Vallerand, Diane& Brault, Antoine& Saleem, Ammar& Arnason, John T.& Musallam, Lina…[et al.]. Populus balsamifera Extract and Its Active Component Salicortin Reduce Obesity and Attenuate Insulin Resistance in a Diet-Induced Obese Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-451661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451661