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Expression of EpCAM Increases in the Hepatitis B Related and the Treatment-Resistant Hepatocellular Carcinoma
Joint Authors
Kogure, Takayuki
Kondo, Yasuteru
Ninomiya, Masashi
Iwata, Tomoaki
Morosawa, Tatsuki
Shimosegawa, Tooru
Kimura, Osamu
Kakazu, Eiji
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Increasing evidence supports the important role of cancer stem cells (CSCs).
Many reports suggest that epithelial cell adhesion molecule (EpCAM) is a useful marker for cancer stem cells in hepatocellular carcinoma (HCC).
To elucidate the mechanisms of cancer stem cells, the development of specific molecular targeted drugs has become very important.
In the present study, we examined the EpCAM expression pattern and its characteristic expression in resected HCC.
We studied the drug resistance of EpCAM expression cells.
EpCAM expression was detected significantly more frequently with hepatitis B virus (HBV) than with other etiologies.
In HCC resection patients who had received prior treatment (transcatheter arterial embolization or hepatic arterial infusion chemotherapy), EpCAM was strongly expressed.
In particular, very strong expression was observed after hepatic arterial infusion chemotherapy.
The PLC/PRF/5 human HCC cell line expressed bimodal EpCAM, and EpCAM-positive cells had CSC cell potency.
The EpCAM expression in EpCAM-positive cells increased significantly by treatment with cisplatin.
EpCAM-positive cells showed better viability than EpCAM-negative cells when treated with ciplatin.
Collectively, our results suggest that cancer stem cells are highly expressed in hepatitis B and have potential anticancer drug resistance.
American Psychological Association (APA)
Kimura, Osamu& Kondo, Yasuteru& Kogure, Takayuki& Kakazu, Eiji& Ninomiya, Masashi& Iwata, Tomoaki…[et al.]. 2014. Expression of EpCAM Increases in the Hepatitis B Related and the Treatment-Resistant Hepatocellular Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-451697
Modern Language Association (MLA)
Kimura, Osamu…[et al.]. Expression of EpCAM Increases in the Hepatitis B Related and the Treatment-Resistant Hepatocellular Carcinoma. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-451697
American Medical Association (AMA)
Kimura, Osamu& Kondo, Yasuteru& Kogure, Takayuki& Kakazu, Eiji& Ninomiya, Masashi& Iwata, Tomoaki…[et al.]. Expression of EpCAM Increases in the Hepatitis B Related and the Treatment-Resistant Hepatocellular Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-451697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451697