Immunohistochemical Detection of Receptor-Associated Protein in Normal Human Brain and Alzheimer's Disease
Joint Authors
Source
Pathology Research International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
This study is one of the few to characterize immunohistochemically the distribution and localization of Receptor-Associated Protein (RAP) in human autopsy brain.
The results show prominent cortical neuronal localization.
RAP is clearly identified in large neuronal dendritic/axonal processes.
RAP is expressed in both large pyramidal and smaller interneurons.
Occasional, much less frequent RAP is detectable in glial cells in white matter, which appear to be predominantly astrocytic.
Although RAP is detectable immunohistochemically in Alzheimer's disease autopsy brain, the level of expression appears significantly reduced relative to age-matched control brains.
These results suggest, at the immunohistochemical level, that there is a reduction of RAP protein in Alzheimer's disease brain (cortex).
In terms of Alzheimer's disease pathophysiology, a reduction of neuronal RAP could then lead to reduced membrane expression of LRP, since RAP has also been shown to be an LRP antagonist.
American Psychological Association (APA)
Provias, John& Jeynes, Brian. 2009. Immunohistochemical Detection of Receptor-Associated Protein in Normal Human Brain and Alzheimer's Disease. Pathology Research International،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-451755
Modern Language Association (MLA)
Provias, John& Jeynes, Brian. Immunohistochemical Detection of Receptor-Associated Protein in Normal Human Brain and Alzheimer's Disease. Pathology Research International No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-451755
American Medical Association (AMA)
Provias, John& Jeynes, Brian. Immunohistochemical Detection of Receptor-Associated Protein in Normal Human Brain and Alzheimer's Disease. Pathology Research International. 2009. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-451755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451755