![](/images/graphics-bg.png)
Comparative Analysis of Context-Dependent Mutagenesis in Humans and Fruit Flies
Joint Authors
Alexeevski, Andrey V.
Panchin, Alexander Y.
Panchin, Yuri V.
Medvedeva, Sofya A.
Spirin, Sergey A.
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In general, mutation frequencies are context-dependent: specific adjacent nucleotides may influence the probability to observe a specific type of mutation in a genome.
Recently, several hypermutable motifs were identified in the human genome.
Namely, there is an increased frequency of T>C mutations in the second position of the words ATTG and ATAG and an increased frequency of A>C mutations in the first position of the word ACAA.
Previous studies have also shown that there is a remarkable difference between the mutagenesis of humans and drosophila.
While C>T mutations are overrepresented in the CG context in humans (and other vertebrates), this mutation regularity is not observed in Drosophila melanogaster.
Such differences in the observed regularities of mutagenesis between representatives of different taxa might reflect differences in the mechanisms involved in mutagenesis.
We performed a systematical comparison of mutation regularities within 2–4 bp contexts in Homo sapiens and Drosophila melanogaster and found that the aforementioned contexts are not hypermutable in fruit flies.
It seems that most mutation contexts affect mutation rates in a similar manner in H.
sapiens and D.
melanogaster; however, several important exceptions are noted and discussed.
American Psychological Association (APA)
Medvedeva, Sofya A.& Panchin, Alexander Y.& Alexeevski, Andrey V.& Spirin, Sergey A.& Panchin, Yuri V.. 2013. Comparative Analysis of Context-Dependent Mutagenesis in Humans and Fruit Flies. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-451764
Modern Language Association (MLA)
Medvedeva, Sofya A.…[et al.]. Comparative Analysis of Context-Dependent Mutagenesis in Humans and Fruit Flies. International Journal of Genomics No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-451764
American Medical Association (AMA)
Medvedeva, Sofya A.& Panchin, Alexander Y.& Alexeevski, Andrey V.& Spirin, Sergey A.& Panchin, Yuri V.. Comparative Analysis of Context-Dependent Mutagenesis in Humans and Fruit Flies. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-451764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451764