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Metabolomic Characterization of Ovarian Epithelial Carcinomas by HRMAS-NMR Spectroscopy
Joint Authors
Piotto, M.
Moussallieh, F.-M.
Namer, I. J.
Elbayed, K.
Neuville, A.
Ben Sellem, D.
Lang-Averous, G.
Bellocq, J.-P.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
The objectives of the present study are to determine if a metabolomic study by HRMAS-NMR can (i) discriminate between different histological types of epithelial ovarian carcinomas and healthy ovarian tissue, (ii) generate statistical models capable of classifying borderline tumors and (iii) establish a potential relationship with patient's survival or response to chemotherapy.
Methods.
36 human epithelial ovarian tumor biopsies and 3 healthy ovarian tissues were studied using 1H HRMAS NMR spectroscopy and multivariate statistical analysis.
Results.
The results presented in this study demonstrate that the three histological types of epithelial ovarian carcinomas present an effective metabolic pattern difference.
Furthermore, a metabolic signature specific of serous (N-acetyl-aspartate) and mucinous (N-acetyl-lysine) carcinomas was found.
The statistical models generated in this study are able to predict borderline tumors characterized by an intermediate metabolic pattern similar to the normal ovarian tissue.
Finally and importantly, the statistical model of serous carcinomas provided good predictions of both patient's survival rates and the patient's response to chemotherapy.
Conclusions.
Despite the small number of samples used in this study, the results indicate that metabolomic analysis of intact tissues by HRMAS-NMR is a promising technique which might be applicable to the therapeutic management of patients.
American Psychological Association (APA)
Ben Sellem, D.& Elbayed, K.& Neuville, A.& Moussallieh, F.-M.& Lang-Averous, G.& Piotto, M.…[et al.]. 2011. Metabolomic Characterization of Ovarian Epithelial Carcinomas by HRMAS-NMR Spectroscopy. Journal of Oncology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-451810
Modern Language Association (MLA)
Ben Sellem, D.…[et al.]. Metabolomic Characterization of Ovarian Epithelial Carcinomas by HRMAS-NMR Spectroscopy. Journal of Oncology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-451810
American Medical Association (AMA)
Ben Sellem, D.& Elbayed, K.& Neuville, A.& Moussallieh, F.-M.& Lang-Averous, G.& Piotto, M.…[et al.]. Metabolomic Characterization of Ovarian Epithelial Carcinomas by HRMAS-NMR Spectroscopy. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-451810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451810