Beta-Thalassaemia Intermedia : Evaluation of Endocrine and Bone Complications
Joint Authors
Cassin, R.
Marcon, A.
Baldini, M.
Graziadei, G.
Ulivieri, F. M.
Cappellini, Maria Domenica
Spinelli, D.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
Data about endocrine and bone disease in nontransfusion-dependent thalassaemia (NTDT) is scanty.
The aim of our study was to evaluate these complications in β-TI adult patients.
Methods.
We studied retrospectively 70 β-TI patients with mean followup of 20 years.
Data recorded included age, gender, haemoglobin and ferritin levels, biochemical and endocrine tests, liver iron concentration (LIC) from T2*, transfusion regimen, iron chelation, hydroxyurea, splenectomy, and bone mineralization by dual X-ray absorptiometry.
Results.
Thirty-seven (53%) males and 33 (47%) females were studied, with mean age 41±12 years, mean haemoglobin 9.2±1.5 g/dL, median ferritin 537 (range 14–4893), and mean LIC 7.6±6.4 mg Fe/g dw.
Thirty-three patients (47%) had been transfused, occasionally (24/33; 73%) or regularly (9/33; 27%); 37/70 (53%) had never been transfused; 34/70 patients had been splenectomized (49%); 39 (56%) were on chelation therapy; and 11 (16%) were on hydroxyurea.
Endocrinopathies were found in 15 patients (21%): 10 hypothyroidism, 3 hypogonadism, 2 impaired glucose tolerance (IGT), and one diabetes.
Bone disease was observed in 53/70 (76%) patients, osteoporosis in 26/53 (49%), and osteopenia in 27/53 (51%).
Discussion and Conclusions.
Bone disease was found in most patients in our study, while endocrinopathies were highly uncommon, especially hypogonadism.
We speculate that low iron burden may protect against endocrinopathy development.
American Psychological Association (APA)
Baldini, M.& Marcon, A.& Cassin, R.& Ulivieri, F. M.& Spinelli, D.& Cappellini, Maria Domenica…[et al.]. 2014. Beta-Thalassaemia Intermedia : Evaluation of Endocrine and Bone Complications. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-451856
Modern Language Association (MLA)
Baldini, M.…[et al.]. Beta-Thalassaemia Intermedia : Evaluation of Endocrine and Bone Complications. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-451856
American Medical Association (AMA)
Baldini, M.& Marcon, A.& Cassin, R.& Ulivieri, F. M.& Spinelli, D.& Cappellini, Maria Domenica…[et al.]. Beta-Thalassaemia Intermedia : Evaluation of Endocrine and Bone Complications. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-451856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451856