![](/images/graphics-bg.png)
The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi
Joint Authors
Nogueira, Natália Pereira de Almeida
Paes, Marcia Cristina
Souza, Cíntia Fernandes de
Meyer-Fernandes, José Roberto
Cosentino-Gomes, Daniela
Source
Journal of Parasitology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Trypanosoma cruzi, the protozoan responsible for Chagas disease, has a complex life cycle comprehending two distinct hosts and a series of morphological and functional transformations.
Hemoglobin degradation inside the insect vector releases high amounts of heme, and this molecule is known to exert a number of physiological functions.
Moreover, the absence of its complete biosynthetic pathway in T.
cruzi indicates heme as an essential molecule for this trypanosomatid survival.
Within the hosts, T.
cruzi has to cope with sudden environmental changes especially in the redox status and heme is able to increase the basal production of reactive oxygen species (ROS) which can be also produced as byproducts of the parasite aerobic metabolism.
In this regard, ROS sensing is likely to be an important mechanism for the adaptation and interaction of these organisms with their hosts.
In this paper we discuss the main features of heme and ROS susceptibility in T.
cruzi biology.
American Psychological Association (APA)
Paes, Marcia Cristina& Cosentino-Gomes, Daniela& Souza, Cíntia Fernandes de& Nogueira, Natália Pereira de Almeida& Meyer-Fernandes, José Roberto. 2011. The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-451859
Modern Language Association (MLA)
Paes, Marcia Cristina…[et al.]. The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi. Journal of Parasitology Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-451859
American Medical Association (AMA)
Paes, Marcia Cristina& Cosentino-Gomes, Daniela& Souza, Cíntia Fernandes de& Nogueira, Natália Pereira de Almeida& Meyer-Fernandes, José Roberto. The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-451859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451859