The 5-Lipoxygenase as a Common Pathway for Pathological Brain and Vascular Aging
Joint Authors
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Epidemiological studies indicate age as a strong risk factor for developing cardiovascular and neurodegenerative diseases.
During the aging process, changes in the expression of particular genes can influence the susceptibility to these diseases.
5-Lipoxygenase (5-LO) by oxidizing fatty acids forms leukotrienes, potent mediators of oxidative and inflammatory reactions, two key pathogenic events in both clinical settings.
This enzyme is widely distributed in the cardiovascular as well as in the central nervous system, where its expression levels increase with age, suggesting that it may be involved in their diseases of aging.
The central theme of this article is that during aging, 5-LO acts as biologic link between different stressors and the development of cardiovascular and neurodegenerative diseases.
We hypothesize that the age-dependent upregulation of 5-LO represents a “priming” factor in the vasculature as well as in the brain, where a subsequent exposure to triggering stimuli (i.e., infections) leads to an abnormal chronic inflammatory reaction, and ultimately results in increased organ vulnerability and functional deficits.
American Psychological Association (APA)
Chu, Jin& Praticò, Domenico. 2009. The 5-Lipoxygenase as a Common Pathway for Pathological Brain and Vascular Aging. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-451865
Modern Language Association (MLA)
Chu, Jin& Praticò, Domenico. The 5-Lipoxygenase as a Common Pathway for Pathological Brain and Vascular Aging. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-451865
American Medical Association (AMA)
Chu, Jin& Praticò, Domenico. The 5-Lipoxygenase as a Common Pathway for Pathological Brain and Vascular Aging. Cardiovascular Psychiatry and Neurology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-451865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451865