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Concentration-Dependent Protection by Ethanol Extract of Propolis against γ-Ray-Induced Chromosome Damage in Human Blood Lymphocytes
Joint Authors
Sahuquillo, V.
Saiz, M.
Villaescusa, J. I.
Almonacid, M.
Serrano, J.
Sebastià, N.
Barquinero, J. F.
Montoro, A.
Verdú, G.
Montoro, A.
Soriano, Jose M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Radioprotection with natural products may be relevant to the mitigation of ionizing radiation-induced damage in mammalian systems; in this sense, propolis extracts have shown effects such as antioxidant, antitumoral, anti-inflammatory, and immunostimulant.
We report for the first time a cytogenetic study to evaluate the radioprotective effect, in vitro, of propolis against radiation-induced chromosomal damage.
Lymphocytes were cultured with increasing concentrations of ethanol extract of propolis (EEP), including 20, 40, 120, 250, 500, 750, 1000, and 2000 μg mL−1 and then exposed to 2 Gy γ-rays.
A significant and concentration-dependent decrease is observed in the frequency of chromosome aberrations in samples treated with EEP.
The protection against the formation of dicentrics was concentration-dependent, with a maximum protection at 120 μg mL−1 of EEP.
The observed frequency of dicentrics is described as negative exponential function, indicating that the maximum protectible fraction of dicentrics is approximately 44%.
Free radical scavenging and antioxidant activities are the mechanisms that these substances use to protect cells from ionizing radiation.
American Psychological Association (APA)
Montoro, A.& Barquinero, J. F.& Almonacid, M.& Montoro, A.& Sebastià, N.& Verdú, G.…[et al.]. 2010. Concentration-Dependent Protection by Ethanol Extract of Propolis against γ-Ray-Induced Chromosome Damage in Human Blood Lymphocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-451886
Modern Language Association (MLA)
Montoro, A.…[et al.]. Concentration-Dependent Protection by Ethanol Extract of Propolis against γ-Ray-Induced Chromosome Damage in Human Blood Lymphocytes. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-451886
American Medical Association (AMA)
Montoro, A.& Barquinero, J. F.& Almonacid, M.& Montoro, A.& Sebastià, N.& Verdú, G.…[et al.]. Concentration-Dependent Protection by Ethanol Extract of Propolis against γ-Ray-Induced Chromosome Damage in Human Blood Lymphocytes. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-451886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451886