Cisplatin Tumor Biodistribution and Efficacy after Intratumoral Injection of a Biodegradable Extended Release Implant
Joint Authors
Domb, Abraham J.
Shikanov, Sergey
Golenser, Jacob
Vaisman, Boris
Shikanov, Ariella
Source
Chemotherapy Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Local delivery of chemotherapeutic drugs has long been recognized as a potential method for reaching high drug doses at the target site while minimizing systemic exposure.
Cisplatin is one of the most effective chemotherapeutic agents for the treatment of various tumors; however, its systemic toxicity remains the primary dose-limiting factor.
Here we report that incorporation of cisplatin into a fatty acid-based polymer carrier followed by a local injection into the solid tumor resulted in a successful tumor growth inhibition in heterotopic mouse bladder tumor model in mice.
Platinum concentration in the tumor tissue surrounding the injected implant remained above the therapeutic level up to 14 days after the injection, while the plasma levels were several orders of magnitude lower comparing to systemic delivery.
The reported delivery system increased the maximum tolerated dose of cisplatin 5 times compared to systemic delivery, thus potentially improving antitumor efficacy of cisplatin in solid tumor model.
American Psychological Association (APA)
Shikanov, Ariella& Shikanov, Sergey& Vaisman, Boris& Golenser, Jacob& Domb, Abraham J.. 2011. Cisplatin Tumor Biodistribution and Efficacy after Intratumoral Injection of a Biodegradable Extended Release Implant. Chemotherapy Research and Practice،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-451906
Modern Language Association (MLA)
Shikanov, Ariella…[et al.]. Cisplatin Tumor Biodistribution and Efficacy after Intratumoral Injection of a Biodegradable Extended Release Implant. Chemotherapy Research and Practice No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-451906
American Medical Association (AMA)
Shikanov, Ariella& Shikanov, Sergey& Vaisman, Boris& Golenser, Jacob& Domb, Abraham J.. Cisplatin Tumor Biodistribution and Efficacy after Intratumoral Injection of a Biodegradable Extended Release Implant. Chemotherapy Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-451906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451906