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Mitochondrial Dysfunctions in Neurodegenerative Diseases : Relevance to Alzheimer’s Disease
Joint Authors
Hroudová, Jana
Singh, Namrata
Fišar, Zdeněk
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mitochondrial dysfunctions are supposed to be responsible for many neurodegenerative diseases dominating in Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD).
A growing body of evidence suggests that defects in mitochondrial metabolism and particularly of electron transport chain may play a role in pathogenesis of AD.
Structurally and functionally damaged mitochondria do not produce sufficient ATP and are more prominent in producing proapoptotic factors and reactive oxygen species (ROS), and this can be an early stage of several mitochondrial disorders, including neurodegenerative diseases.
Mitochondrial dysfunctions may be caused by both mutations in mitochondrial or nuclear DNA that code mitochondrial components and by environmental causes.
In the following review, common aspects of mitochondrial impairment concerned about neurodegenerative diseases are summarized including ROS production, impaired mitochondrial dynamics, and apoptosis.
Also, damaged function of electron transport chain complexes and interactions between pathological proteins and mitochondria are described for AD particularly and marginally for PD and HD.
American Psychological Association (APA)
Hroudová, Jana& Singh, Namrata& Fišar, Zdeněk. 2014. Mitochondrial Dysfunctions in Neurodegenerative Diseases : Relevance to Alzheimer’s Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-451907
Modern Language Association (MLA)
Hroudová, Jana…[et al.]. Mitochondrial Dysfunctions in Neurodegenerative Diseases : Relevance to Alzheimer’s Disease. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-451907
American Medical Association (AMA)
Hroudová, Jana& Singh, Namrata& Fišar, Zdeněk. Mitochondrial Dysfunctions in Neurodegenerative Diseases : Relevance to Alzheimer’s Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-451907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451907