Castleman's Disease : A Case Report of the Unicentric Type

Abstract EN

Castleman's disease, or angiofollicular lymph node hyperplasia, is a relatively rare disorder characterized by the benign proliferation of lymphoid tissue related to the chronic human herpes virus 8 (HHV-8) infection and the human immunodeficiency virus (HIV).

Two clinical entities have been described: a unicentric presentation with the disease confined to a single anatomic lymph node and a multicentric presentation characterized by generalized lymphadenopathy and a more aggressive clinical course.

Also, three histopathological subtypes have been described: hyaline-vascular, plasma cell, and a mixed variant.

Preoperative diagnosis of hyaline-vascular Castleman's disease is difficult, and the definitive result is based on postoperative pathological findings.

The gold standard therapy is the complete surgical excision.