Intercellular Interactomics of Human Brain Endothelial Cells and Th17 Lymphocytes : A Novel Strategy for Identifying Therapeutic Targets of CNS Inflammation

Joint Authors

Haqqani, Arsalan S.
Stanimirovic, Danica B.

Source

Cardiovascular Psychiatry and Neurology

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-06-13

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

Leukocyte infiltration across an activated brain endothelium contributes to the neuroinflammation seen in many neurological disorders.

Recent evidence shows that IL-17-producing T-lymphocytes (e.g., Th17 cells) possess brain-homing capability and contribute to the pathogenesis of multiple sclerosis and cerebral ischemia.

The leukocyte transmigration across the endothelium is a highly regulated, multistep process involving intercellular communications and interactions between the leukocytes and endothelial cells.

The molecules involved in the process are attractive therapeutic targets for inhibiting leukocyte brain migration.

We hypothesized and have been successful in demonstrating that molecules of potential therapeutic significance involved in Th17-brain endothelial cell (BEC) communications and interactions can be discovered through the combination of advanced membrane/submembrane proteomic and interactomic methods.

We describe elements of this strategy and preliminary results obtained in method and approach development.

The Th17-BEC interaction network provides new insights into the complexity of the transmigration process mediated by well-organized, subcellularly localized molecular interactions.

These molecules and interactions are potential diagnostic, therapeutic, or theranostic targets for treatment of neurological conditions accompanied or caused by leukocyte infiltration.

American Psychological Association (APA)

Haqqani, Arsalan S.& Stanimirovic, Danica B.. 2011. Intercellular Interactomics of Human Brain Endothelial Cells and Th17 Lymphocytes : A Novel Strategy for Identifying Therapeutic Targets of CNS Inflammation. Cardiovascular Psychiatry and Neurology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-451949

Modern Language Association (MLA)

Haqqani, Arsalan S.& Stanimirovic, Danica B.. Intercellular Interactomics of Human Brain Endothelial Cells and Th17 Lymphocytes : A Novel Strategy for Identifying Therapeutic Targets of CNS Inflammation. Cardiovascular Psychiatry and Neurology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-451949

American Medical Association (AMA)

Haqqani, Arsalan S.& Stanimirovic, Danica B.. Intercellular Interactomics of Human Brain Endothelial Cells and Th17 Lymphocytes : A Novel Strategy for Identifying Therapeutic Targets of CNS Inflammation. Cardiovascular Psychiatry and Neurology. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-451949

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-451949