Low-Level Laser-Accelerated Peripheral Nerve Regeneration within a Reinforced Nerve Conduit across a Large Gap of the Transected Sciatic Nerve in Rats
Joint Authors
Chan, Shiuh-Chuan
Shen, Chiung-Chyi
Yang, Yi-Chin
Liu, Bai-Shuan
Huang, Tsung-Bin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study proposed a novel combination of neural regeneration techniques for the repair of damaged peripheral nerves.
A biodegradable nerve conduit containing genipin-cross-linked gelatin was annexed using beta-tricalcium phosphate (TCP) ceramic particles (genipin-gelatin-TCP, GGT) to bridge the transection of a 15 mm sciatic nerve in rats.
Two trigger points were irradiated transcutaneously using 660 nm of gallium-aluminum arsenide phosphide (GaAlAsP) via laser diodes for 2 min daily over 10 consecutive days.
Walking track analysis showed a significant improvement in sciatic functional index (SFI) (P<0.01) and pronounced improvement in the toe spreading ability of rats undergoing laser stimulation.
Electrophysiological measurements (peak amplitude and area) illustrated by compound muscle action potential (CMAP) curves demonstrated that laser stimulation significantly improved nerve function and reduced muscular atrophy.
Histomorphometric assessments revealed that laser stimulation accelerated nerve regeneration over a larger area of neural tissue, resulting in axons of greater diameter and myelin sheaths of greater thickness than that observed in rats treated with nerve conduits alone.
Motor function, electrophysiological reactions, muscular reinnervation, and histomorphometric assessments all demonstrate that the proposed therapy accelerated the repair of transected peripheral nerves bridged using a GGT nerve conduit.
American Psychological Association (APA)
Shen, Chiung-Chyi& Yang, Yi-Chin& Huang, Tsung-Bin& Chan, Shiuh-Chuan& Liu, Bai-Shuan. 2013. Low-Level Laser-Accelerated Peripheral Nerve Regeneration within a Reinforced Nerve Conduit across a Large Gap of the Transected Sciatic Nerve in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-451968
Modern Language Association (MLA)
Shen, Chiung-Chyi…[et al.]. Low-Level Laser-Accelerated Peripheral Nerve Regeneration within a Reinforced Nerve Conduit across a Large Gap of the Transected Sciatic Nerve in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-451968
American Medical Association (AMA)
Shen, Chiung-Chyi& Yang, Yi-Chin& Huang, Tsung-Bin& Chan, Shiuh-Chuan& Liu, Bai-Shuan. Low-Level Laser-Accelerated Peripheral Nerve Regeneration within a Reinforced Nerve Conduit across a Large Gap of the Transected Sciatic Nerve in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-451968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451968