Interleukin-6 and Vitamin D Status during High-Intensity Resistance Training in Patients with Chronic Kidney Disease

Abstract EN

Background.

The aim of this study was to investigate IL-6 and 25-hydroxyvitamin D (25-OH D) associations with muscle size and muscle function in dialysis patients.

Methods.

Patients were included in a 16-week control period followed by 16 weeks of high-intensity resistance training thrice weekly.

IL-6 and 25-OH D were analysed after an over-night fast.

Muscle fibre size was analysed in biopsies from m.

vastus lateralis.

Muscle power was tested using a Leg Extensor Power Rig.

Results.

Patients (n=36) with IL-6 ≥ 6.49 pg/ml (median) were older and had decreased muscle power and a reduced protein intake (P<0.05) compared with patients with IL-6 < 6.49 pg/ml.

IL-6 was not associated with muscle fibre size.

Vitamin D deficiency (25-OH D < 50 nmol/l) was present in 51% of the patients and not associated with muscle power.

IL-6 remained unchanged during the training period, whilst muscle power increased by 20–23% (P<0.001).

Conclusion.

Elevated IL-6 values were associated with decreased muscle power but not with decreased muscle fibre size.

Half of the patients were suffering from vitamin D deficiency, which was not associated with muscle power.

IL-6 was unchanged by high-intensity resistance training in dialysis patients in this study.