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Endothelial Cells and Astrocytes : A Concerto en Duo in Ischemic Pathophysiology
Joint Authors
Vincent, Bérézowski
Badaut, Jérôme
Fukuda, Andrew M.
Cecchelli, Roméo
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The neurovascular/gliovascular unit has recently gained increased attention in cerebral ischemic research, especially regarding the cellular and molecular changes that occur in astrocytes and endothelial cells.
In this paper we summarize the recent knowledge of these changes in association with edema formation, interactions with the basal lamina, and blood-brain barrier dysfunctions.
We also review the involvement of astrocytes and endothelial cells with recombinant tissue plasminogen activator, which is the only FDA-approved thrombolytic drug after stroke.
However, it has a narrow therapeutic time window and serious clinical side effects.
Lastly, we provide alternative therapeutic targets for future ischemia drug developments such as peroxisome proliferator- activated receptors and inhibitors of the c-Jun N-terminal kinase pathway.
Targeting the neurovascular unit to protect the blood-brain barrier instead of a classical neuron-centric approach in the development of neuroprotective drugs may result in improved clinical outcomes after stroke.
American Psychological Association (APA)
Vincent, Bérézowski& Fukuda, Andrew M.& Cecchelli, Roméo& Badaut, Jérôme. 2012. Endothelial Cells and Astrocytes : A Concerto en Duo in Ischemic Pathophysiology. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-452025
Modern Language Association (MLA)
Vincent, Bérézowski…[et al.]. Endothelial Cells and Astrocytes : A Concerto en Duo in Ischemic Pathophysiology. International Journal of Cell Biology No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-452025
American Medical Association (AMA)
Vincent, Bérézowski& Fukuda, Andrew M.& Cecchelli, Roméo& Badaut, Jérôme. Endothelial Cells and Astrocytes : A Concerto en Duo in Ischemic Pathophysiology. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-452025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452025