The Role of Rho Kinase in Sex-Dependent Vascular Dysfunction in Type 1 Diabetes
Joint Authors
Lamping, Kathryn G.
Nuno, Daniel W.
Source
Experimental Diabetes Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We hypothesized that rho/rho kinase plays a role in sex differences in vascular dysfunction of diabetics.
Contractions to serotonin were greater in isolated aortic rings from nondiabetic males versus females and increased further in streptozotocin-induced diabetic males but not females.
The increased contractions to serotonin in males were reduced by inhibitors of rho kinase (fasudil, Y27632 and H1152) despite no change in expression of rhoA or rho kinase.
Contractions to U46619 were not altered by fasudil or Y27632 or the presence of diabetes.
In contrast to acute effects of fasudil, chronic treatment with fasudil increased contractions to serotonin in aorta from both non-diabetic and diabetic males.
In summary, serotonin-induced contractions were increased in aorta from diabetic males but not females.
Although administration of rho kinase inhibitors acutely decreased contractions to serotonin, long-term treatment with fasudil increased contractions.
Long-term fasudil treatment may increase compensatory mechanisms to enhance vasoconstrictions.
American Psychological Association (APA)
Nuno, Daniel W.& Lamping, Kathryn G.. 2010. The Role of Rho Kinase in Sex-Dependent Vascular Dysfunction in Type 1 Diabetes. Experimental Diabetes Research،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-452033
Modern Language Association (MLA)
Nuno, Daniel W.& Lamping, Kathryn G.. The Role of Rho Kinase in Sex-Dependent Vascular Dysfunction in Type 1 Diabetes. Experimental Diabetes Research No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-452033
American Medical Association (AMA)
Nuno, Daniel W.& Lamping, Kathryn G.. The Role of Rho Kinase in Sex-Dependent Vascular Dysfunction in Type 1 Diabetes. Experimental Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-452033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452033