Lung Dendritic Cell Developmental Programming, Environmental Stimuli, and Asthma in Early Periods of Life
Joint Authors
Welliver, Robert C.
Singh, Bhupinder
Awasthi, Shanjana
Dietert, Rodney R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dendritic cells (DCs) are important cells of our innate immune system.
Their role is critical in inducing adaptive immunity, tolerance, or allergic response in peripheral organs—lung and skin.
The lung DCs are not developed prenatally before birth.
The DCs develop after birth presumably during the first year of life; exposures to any foreign antigen or infectious organisms during this period can significantly affect DC developmental programming and generation of distinct DC phenotypes and functions.
These changes can have both short-term and long-term health effects which may be very relevant in childhood asthma and predisposition for a persistent response in adulthood.
An understanding of DC development at molecular and cellular levels can help in protecting neonates and infants against problematic environmental exposures and developmental immunotoxicity.
This knowledge can eventually help in designing novel pharmacological modulators to skew the DC characteristics and immune responses to benefit the host across a lifetime.
American Psychological Association (APA)
Awasthi, Shanjana& Singh, Bhupinder& Welliver, Robert C.& Dietert, Rodney R.. 2012. Lung Dendritic Cell Developmental Programming, Environmental Stimuli, and Asthma in Early Periods of Life. Journal of Allergy،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-452043
Modern Language Association (MLA)
Awasthi, Shanjana…[et al.]. Lung Dendritic Cell Developmental Programming, Environmental Stimuli, and Asthma in Early Periods of Life. Journal of Allergy No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-452043
American Medical Association (AMA)
Awasthi, Shanjana& Singh, Bhupinder& Welliver, Robert C.& Dietert, Rodney R.. Lung Dendritic Cell Developmental Programming, Environmental Stimuli, and Asthma in Early Periods of Life. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-452043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452043