Enantioselective Synthesis of Antiepileptic Agent, (−)-Levetiracetam, through Evans Asymmetric Strategy
Joint Authors
Mukkanti, K.
Nigam, Satish
Buchi Reddy, R.
Chandra Babu, K.
Suresh, K.
Madhusudhan, G.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A practical and efficient enantioselective synthesis of antiepileptic drug, (−)-Levetiracetam, has been described in five steps (33.0% overall yield) and high optical purity (99.0% ee), using Evans asymmetric strategy for α-alkylation of carbonyl functionality as the key step.
The simplicity of the experimental procedures and high stereochemical outcome make this method synthetically attractive for preparing the target compound on multigram scales.
American Psychological Association (APA)
Chandra Babu, K.& Buchi Reddy, R.& Mukkanti, K.& Suresh, K.& Madhusudhan, G.& Nigam, Satish. 2012. Enantioselective Synthesis of Antiepileptic Agent, (−)-Levetiracetam, through Evans Asymmetric Strategy. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-452052
Modern Language Association (MLA)
Chandra Babu, K.…[et al.]. Enantioselective Synthesis of Antiepileptic Agent, (−)-Levetiracetam, through Evans Asymmetric Strategy. Journal of Chemistry No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-452052
American Medical Association (AMA)
Chandra Babu, K.& Buchi Reddy, R.& Mukkanti, K.& Suresh, K.& Madhusudhan, G.& Nigam, Satish. Enantioselective Synthesis of Antiepileptic Agent, (−)-Levetiracetam, through Evans Asymmetric Strategy. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-452052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452052