IschemiaReperfusion Injury in Liver Surgery and Transplantation : Pathophysiology
Joint Authors
Schemmer, Peter
Müller, Martina
Büchler, Markus W.
Steinebrunner, Niels
Weigand, Kilian
Brost, Sylvia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Liver ischemia/reperfusion (IR) injury is caused by a heavily toothed network of interactions of cells of the immune system, cytokine production, and reduced microcirculatory blood flow in the liver.
These complex networks are further elaborated by multiple intracellular pathways activated by cytokines, chemokines, and danger-associated molecular patterns.
Furthermore, intracellular ionic disturbances and especially mitochondrial disorders play an important role leading to apoptosis and necrosis of hepatocytes in IR injury.
Overall, enhanced production of reactive oxygen species, found very early in IR injury, plays an important role in liver tissue damage at several points within these complex networks.
Many contributors to IR injury are only incompletely understood so far.
This paper tempts to give an overview of the different mechanisms involved in the formation of IR injury.
Only by further elucidation of these complex mechanisms IR injury can be understood and possible therapeutic strategies can be improved or be developed.
American Psychological Association (APA)
Weigand, Kilian& Brost, Sylvia& Steinebrunner, Niels& Büchler, Markus W.& Schemmer, Peter& Müller, Martina. 2012. IschemiaReperfusion Injury in Liver Surgery and Transplantation : Pathophysiology. HPB Surgery،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-452067
Modern Language Association (MLA)
Weigand, Kilian…[et al.]. IschemiaReperfusion Injury in Liver Surgery and Transplantation : Pathophysiology. HPB Surgery No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-452067
American Medical Association (AMA)
Weigand, Kilian& Brost, Sylvia& Steinebrunner, Niels& Büchler, Markus W.& Schemmer, Peter& Müller, Martina. IschemiaReperfusion Injury in Liver Surgery and Transplantation : Pathophysiology. HPB Surgery. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-452067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452067