Lipid Droplet Binding of Hepatitis C Virus Core Protein Genotype 3
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Hepatitis C virus (HCV) genotype 3 is known to cause steatosis (fatty liver) that is more frequent and severe than other genotypes.
We previously identified sequence elements within genotype 3 HCV Core domain 3 that were sufficient for lipid accumulation.
Aims.
We examined various genotype 3 Core domains for lipid droplet localization and compared the lipid droplet binding regions of domain 2 with a genotype 1 isolate.
Methods.
We generated HCV Core domain constructs fused with green fluorescent protein and performed immunofluorescence to visualize lipid droplets.
Results.
Constructs containing HCV Core domain 2 are appropriately localized to lipid droplets with varying degrees of efficiency.
When compared to genotype 1, there are polymorphisms within domain 2 that do not appear to alter lipid droplet localization.
Conclusions.
In summary, the differences in a steatosis-associated HCV Core genotype 3 isolate do not appear to involve altered lipid droplet localization.
American Psychological Association (APA)
Qiang, Guan& Jhaveri, Ravi. 2012. Lipid Droplet Binding of Hepatitis C Virus Core Protein Genotype 3. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-452068
Modern Language Association (MLA)
Qiang, Guan& Jhaveri, Ravi. Lipid Droplet Binding of Hepatitis C Virus Core Protein Genotype 3. ISRN Gastroenterology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-452068
American Medical Association (AMA)
Qiang, Guan& Jhaveri, Ravi. Lipid Droplet Binding of Hepatitis C Virus Core Protein Genotype 3. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-452068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452068